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Midbrain Tet1 dosage defines inter-individual binge-eating susceptibility
Binge-eating disorder (BED) is the most common eating disorder worldwide and carries life-altering comorbidities. While genetic and …
Tim Gruber, Robert A Chesters, Luca Fagnocchi, Xinyang Yu, Zhen Fu, Kristin Gallik, Heiko Backes, Robert Vaughan, Melanie Huber, Meri De Angelis, Josef Gullmets, Holly Dykstra, Stefanos Apostle, Taylor Cook, Justin Kulchycki, Lisa DeCamp, Timo Dirk Mueller, Katharina Timper, Sylvane Desrivieres, Rachel N Lippert, John Andrew Pospisilik
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Midbrain Tet1 dosage defines inter-individual binge-eating susceptibility
Neuroendocrine gut–brain signaling in obesity
The past decades have witnessed the rise and fall of several, largely unsuccessful, therapeutic attempts to bring the escalating …
Tim Gruber, Franziska Lechner, Jean-Philippe Krieger, Cristina García-Cáceres
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Neuroendocrine gut–brain signaling in obesity
HDAC5 controls a hypothalamic STAT5b-TH axis, the sympathetic activation of ATP-consuming futile cycles and adult-onset obesity in male mice
With age, metabolic perturbations accumulate to elevate our obesity burden. While age-onset obesity is mostly driven by a sedentary …
Raian E. Contreras, Tim Gruber, Ismael González-García, Sonja C. Schriever, Meri De Angelis, Noemi Mallet, Miriam Bernecker, Beata Legutko, Dhiraj Kabra, Mathias Schmidt, Matthias H. Tschöp, Ruth Gutierrez-Aguilar, Jane Mellor, Cristina García-Cáceres, Paul T. Pfluger
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Oxytocin does not acutely improve glucose tolerance in men with type 2 diabetes
Nina Goll, Nina Moszka, Konstantinos Kantartzis, Hubert Preissl, Tim Gruber, Louise Fritsche, Reiner Jumpertz‐von Schwarzenberg, Cristina García‐Cáceres, Andreas Fritsche, Manfred Hallschmid
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Global, neuronal or $β$ cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity
Gerald Grandl, Gustav Colldén, Jin Feng, Sreya Bhattacharya, Felix Klingelhuber, Leopold Schomann, Sara Bilekova, Ansarullah, Weiwei Xu, Fataneh Fathi Far, Monica Tost, Tim Gruber, Aimée Bastidas-Ponce, Qian Zhang, Aaron Novikoff, Arkadiusz Liskiewicz, Daniela Liskiewicz, Cristina García-Cáceres, Annette Feuchtinger, Matthias H. Tschöp, Natalie Krahmer, Heiko Lickert, Timo D. Müller
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High-calorie diets uncouple hypothalamic oxytocin neurons from a gut-to-brain satiation pathway via $ąppa$-opioid signaling
Oxytocin-expressing paraventricular hypothalamic neurons (PVN^OT neurons) integrate afferent signals from the gut, including …
Tim Gruber, Franziska Lechner, Cahuê Murat, Raian E. Contreras, Eva Sanchez-Quant, Viktorian Miok, Konstantinos Makris, Ophelia Le Thuc, Ismael González-García, Elena García-Clavé, Ferdinand Althammer, Quirin Krabichler, Lisa M. DeCamp, Russell G. Jones, Dominik Lutter, Rhiannan H. Williams, Paul T. Pfluger, Timo D. Müller, Stephen C. Woods, John Andrew Pospisilik, Celia P. Martinez-Jimenez, Matthias H. Tschöp, Valery Grinevich, Cristina García-Cáceres
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High-calorie diets uncouple hypothalamic oxytocin neurons from a gut-to-brain satiation pathway via $ąppa$-opioid signaling
Epigenetic dosage identifies two major and functionally distinct $β$ cell subtypes
Erez Dror, Luca Fagnocchi, Vanessa Wegert, Stefanos Apostle, Brooke Grimaldi, Tim Gruber, Ilaria Panzeri, Steffen Heyne, Kira Daniela Höffler, Victor Kreiner, Reagan Ching, Tess Tsai-Hsiu Lu, Ayush Semwal, Ben Johnson, Parijat Senapati, Adelheid Lempradl, Dustin Schones, Axel Imhof, Hui Shen, John Andrew Pospisilik
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Estradiol regulates leptin sensitivity to control feeding via hypothalamic Cited1
Ismael González-García, Elena García-Clavé, Alberto Cebrian-Serrano, Ophelia Le Thuc, Raian E. Contreras, Yanjun Xu, Tim Gruber, Sonja C. Schriever, Beata Legutko, Jutta Lintelmann, Jerzy Adamski, Wolfgang Wurst, Timo D. Müller, Stephen C. Woods, Paul T. Pfluger, Matthias H. Tschöp, Alexandre Fisette, Cristina García-Cáceres
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Estradiol regulates leptin sensitivity to control feeding via hypothalamic Cited1
Ismael González-García, Elena García-Clavé, Alberto Cebrian-Serrano, Ophelia Le Thuc, Raian E. Contreras, Yanjun Xu, Tim Gruber, Sonja C. Schriever, Beata Legutko, Jutta Lintelmann, Jerzy Adamski, Wolfgang Wurst, Timo D. Müller, Stephen C. Woods, Paul T. Pfluger, Matthias H. Tschöp, Alexandre Fisette, Cristina García-Cáceres
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The dietary sweetener sucralose is a negative modulator of T cell-mediated responses
Fabio Zani, Julianna Blagih, Tim Gruber, Michael D. Buck, Nicholas Jones, Marc Hennequart, Clare L. Newell, Steven E. Pilley, Pablo Soro-Barrio, Gavin Kelly, Nathalie M. Legrave, Eric C. Cheung, Ian S. Gilmore, Alex P. Gould, Cristina García-Cáceres, Karen H. Vousden
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