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Coupling of oxytocin and cholecystokinin pathways in the hypothalamus is required for gut-to-brain homeostatic feeding control
Oxytocin-expressing paraventricular hypothalamic neurons (PVNOT neurons) integrate afferent signals from the gut including …
T Gruber, F Lechner, C Murat, RE Contreras, E Sanchez-Quant, V Miok, O Le Thuc, I González-Garcı́a, RH Williams, PT Pfluger, TD Müller, SC Woods, CP Martinez-Jimenez, MH Tschöp, V Grinevich, C Garciá-Cáceres
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Coupling of oxytocin and cholecystokinin pathways in the hypothalamus is required for gut-to-brain homeostatic feeding control
Auto-aggressive CXCR6$mathplus$ CD8 T cells cause liver immune pathology in NASH
Michael Dudek, Dominik Pfister, Sainitin Donakonda, Pamela Filpe, Annika Schneider, Melanie Laschinger, Daniel Hartmann, Norbert Hüser, Philippa Meiser, Felix Bayerl, Donato Inverso, Jennifer Wigger, Marcial Sebode, Rupert Öllinger, Roland Rad, Silke Hegenbarth, Martina Anton, Adrien Guillot, Andrew Bowman, Danijela Heide, Florian Müller, Pierluigi Ramadori, Valentina Leone, Cristina Garcia-Caceres, Tim Gruber, Gabriel Seifert, Agnieszka M. Kabat, Jan-Philipp Mallm, Simon Reider, Maria Effenberger, Susanne Roth, Adrian T. Billeter, Beat Müller-Stich, Edward J. Pearce, Friedrich Koch-Nolte, Rafael Käser, Herbert Tilg, Robert Thimme, Tobias Boettler, Frank Tacke, Jean-Francois Dufour, Dirk Haller, Peter J. Murray, Ron Heeren, Dietmar Zehn, Jan P. Böttcher, Mathias Heikenwälder, Percy A. Knolle
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Insulin action on astrocytes: From energy homeostasis to behaviour
Abstract Astrocytes are specialised glial cells that integrate distinct inputs arising from neurones, other glial cells and the …
Ismael González-García, Tim Gruber, Cristina Garcia-Caceres
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Insulin action on astrocytes: From energy homeostasis to behaviour
Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension
Summary Pathologies of the micro- and macrovascular systems are a hallmark of the metabolic syndrome, which can lead to chronically …
Tim Gruber, Chenchen Pan, Raian E. Contreras, Tobias Wiedemann, Donald A. Morgan, Alicja A. Skowronski, Sandrine Lefort, Cahuê De Bernardis Murat, Ophelia Le Thuc, Beata Legutko, Francisco J. Ruiz-Ojeda, María de la Fuente-Fernández, Angel Luis García-Villalón, Daniel González-Hedström, Melanie Huber, Klara Szigeti-Buck, Timo D. Müller, Siegfried Ussar, Paul Pfluger, Steve C. Woods, Ali Ertürk, Charles A. LeDuc, Kamal Rahmouni, Miriam Granado, Tamas L. Horvath, Matthias H. Tschöp, Cristina Garcia-Caceres
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Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension
The Neuroanatomical Organization of Hypothalamic Feeding Circuits
Based on early experimental lesion findings, the hypothalamus was historically identified as fundamental for balancing energy intake …
Tim Gruber, Stephen C. Woods, Matthias H. Tschöp, Cristina Garcia-Caceres
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Functional identity of hypothalamic melanocortin neurons depends on Tbx3
Heterogeneous populations of hypothalamic neurons orchestrate energy balance via the release of specific signatures of neuropeptides. …
Carmelo Quarta, Alexandre Fisette, Yanjun Xu, Gustav Collden, Beata Legutko, Yu-Ting Tseng, Alexander Reim, Michael Wierer, Maria Caterina De Rosa, Valentina Klaus, Rick Rausch, Vidhu V. Thaker, Elisabeth Graf, Tim M. Strom, Anne-Laure Poher, Tim Gruber, Ophelia Le Thuc, Alberto Cebrian-Serrano, Dhiraj Kabra, Luigi Bellocchio, Stephen C. Woods, Gert O. Pflugfelder, Rubén Nogueiras, Lori Zeltser, Ilona C. Grunwald Kadow, Anne Moon, Cristina Garcia-Caceres, Matthias Mann, Mathias Treier, Claudia A. Doege, Matthias H. Tschöp
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Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes
Pharmacological stimulation of brown adipose tissue (BAT) thermogenesis to increase energy expenditure is progressively being pursued …
Christoffer Clemmensen, Sigrid Jall, Maximilian Kleinert, Carmelo Quarta, Tim Gruber, Josefine Reber, Stephan Sachs, Katrin Fischer, Annette Feuchtinger, Angelos Karlas, Stephanie E. Simonds, Gerald Grandl, Daniela Loher, Eva Sanchez-Quant, Susanne Keipert, Martin Jastroch, Susanna M. Hofmann, Emmani B. M. Nascimento, Patrick Schrauwen, Vasilis Ntziachristos, Michael A. Cowley, Brian Finan, Timo D. Müller, Matthias H. Tschöp
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Chronic D-serine supplementation impairs insulin secretion
The metabolic role of d-serine, a non-proteinogenic NMDA receptor co-agonist, is poorly understood. Conversely, inhibition of …
Lisa Suwandhi, Simone Hausmann, Alexander Braun, Tim Gruber, Silke Heinzmann, Eric Gálvez, Achim Buck, Beata Legutko, Andreas Israel, Annette Feuchtinger, Elizabeth Haythorne, Harald Staiger, Martin Heni, Hans Haring, Ph Schmitt-Kopplin, Axel Walch, Cristina Garcia-Caceres, Matthias Tschöp, Guy Rutter, Siegfried Ussar
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Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability
We report that astrocytic insulin signaling co-regulates hypothalamic glucose sensing and systemic glucose metabolism. Postnatal …
Cristina Garcia-Caceres, Carmelo Quarta, Luis Varela, Yuanqing Gao, Tim Gruber, Beata Legutko, Martin Jastroch, Pia Johansson, Jovica Ninkovic, Chun-Xia Yi, Ophelia Le Thuc, Klara Szigeti-Buck, Weikang Cai, Carola W. Meyer, Paul T. Pfluger, Ana M. Fernandez, Serge Luquet, Stephen C. Woods, Ignacio Torres-Alemán, C. Ronald Kahn, Magdalena Götz, Tamas L. Horvath, Matthias H. Tschöp
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Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability
A New Population of Parvocellular Oxytocin Neurons Controlling Magnocellular Neuron Activity and Inflammatory Pain Processing
Oxytocin (OT) is a neuropeptide elaborated by the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei. Magnocellular OT …
Marina Eliava, Meggane Melchior, H. ~Sophie Knobloch-Bollmann, Jérôme Wahis, Miriam da~Silva~Gouveia, Yan Tang, Alexandru~Cristian Ciobanu, Rodrigo Triana~del~Rio, Lena~C. Roth, Ferdinand Althammer, Virginie Chavant, Yannick Goumon, Tim Gruber, Nathalie Petit-Demoulière, Marta Busnelli, Bice Chini, Linette~L. Tan, Mariela Mitre, Robert~C. Froemke, Moses~V. Chao, Günter Giese, Rolf Sprengel, Rohini Kuner, Pierrick Poisbeau, Peter~H. Seeburg, Ron Stoop, Alexandre Charlet, Valery Grinevich
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