Tim Gruber

Midbrain Tet1 dosage defines inter-individual binge-eating susceptibility

Binge-eating disorder (BED) is the most common eating disorder worldwide and carries life-altering comorbidities. While genetic and …

Tim Gruber, Robert A Chesters, Luca Fagnocchi, Xinyang Yu, Zhen Fu, Kristin Gallik, Heiko Backes, Robert Vaughan, Melanie Huber, Meri De Angelis, Josef Gullmets, Holly Dykstra, Stefanos Apostle, Taylor Cook, Justin Kulchycki, Lisa DeCamp, Timo Dirk Mueller, Katharina Timper, Sylvane Desrivieres, Rachel N Lippert, John Andrew Pospisilik

Midbrain Tet1 dosage defines inter-individual binge-eating susceptibility

Neuroendocrine gut–brain signaling in obesity

The past decades have witnessed the rise and fall of several, largely unsuccessful, therapeutic attempts to bring the escalating …

Tim Gruber, Franziska Lechner, Jean-Philippe Krieger, Cristina García-Cáceres

Neuroendocrine gut–brain signaling in obesity

HDAC5 controls a hypothalamic STAT5b-TH axis, the sympathetic activation of ATP-consuming futile cycles and adult-onset obesity in male mice

With age, metabolic perturbations accumulate to elevate our obesity burden. While age-onset obesity is mostly driven by a sedentary …

Raian E. Contreras, Tim Gruber, Ismael González-García, Sonja C. Schriever, Meri De Angelis, Noemi Mallet, Miriam Bernecker, Beata Legutko, Dhiraj Kabra, Mathias Schmidt, Matthias H. Tschöp, Ruth Gutierrez-Aguilar, Jane Mellor, Cristina García-Cáceres, Paul T. Pfluger

Oxytocin does not acutely improve glucose tolerance in men with type 2 diabetes

Nina Goll, Nina Moszka, Konstantinos Kantartzis, Hubert Preissl, Tim Gruber, Louise Fritsche, Reiner Jumpertz‐von Schwarzenberg, Cristina García‐Cáceres, Andreas Fritsche, Manfred Hallschmid

Global, neuronal or $β$ cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity

Gerald Grandl, Gustav Colldén, Jin Feng, Sreya Bhattacharya, Felix Klingelhuber, Leopold Schomann, Sara Bilekova, Ansarullah, Weiwei Xu, Fataneh Fathi Far, Monica Tost, Tim Gruber, Aimée Bastidas-Ponce, Qian Zhang, Aaron Novikoff, Arkadiusz Liskiewicz, Daniela Liskiewicz, Cristina García-Cáceres, Annette Feuchtinger, Matthias H. Tschöp, Natalie Krahmer, Heiko Lickert, Timo D. Müller

High-calorie diets uncouple hypothalamic oxytocin neurons from a gut-to-brain satiation pathway via $ąppa$-opioid signaling

Oxytocin-expressing paraventricular hypothalamic neurons (PVN^OT neurons) integrate afferent signals from the gut, including …

Tim Gruber, Franziska Lechner, Cahuê Murat, Raian E. Contreras, Eva Sanchez-Quant, Viktorian Miok, Konstantinos Makris, Ophelia Le Thuc, Ismael González-García, Elena García-Clavé, Ferdinand Althammer, Quirin Krabichler, Lisa M. DeCamp, Russell G. Jones, Dominik Lutter, Rhiannan H. Williams, Paul T. Pfluger, Timo D. Müller, Stephen C. Woods, John Andrew Pospisilik, Celia P. Martinez-Jimenez, Matthias H. Tschöp, Valery Grinevich, Cristina García-Cáceres

High-calorie diets uncouple hypothalamic oxytocin neurons from a gut-to-brain satiation pathway via $ąppa$-opioid signaling

Epigenetic dosage identifies two major and functionally distinct $β$ cell subtypes

Erez Dror, Luca Fagnocchi, Vanessa Wegert, Stefanos Apostle, Brooke Grimaldi, Tim Gruber, Ilaria Panzeri, Steffen Heyne, Kira Daniela Höffler, Victor Kreiner, Reagan Ching, Tess Tsai-Hsiu Lu, Ayush Semwal, Ben Johnson, Parijat Senapati, Adelheid Lempradl, Dustin Schones, Axel Imhof, Hui Shen, John Andrew Pospisilik

The dietary sweetener sucralose is a negative modulator of T cell-mediated responses

Fabio Zani, Julianna Blagih, Tim Gruber, Michael D. Buck, Nicholas Jones, Marc Hennequart, Clare L. Newell, Steven E. Pilley, Pablo Soro-Barrio, Gavin Kelly, Nathalie M. Legrave, Eric C. Cheung, Ian S. Gilmore, Alex P. Gould, Cristina García-Cáceres, Karen H. Vousden

Estradiol regulates leptin sensitivity to control feeding via hypothalamic Cited1

Ismael González-García, Elena García-Clavé, Alberto Cebrian-Serrano, Ophelia Le Thuc, Raian E. Contreras, Yanjun Xu, Tim Gruber, Sonja C. Schriever, Beata Legutko, Jutta Lintelmann, Jerzy Adamski, Wolfgang Wurst, Timo D. Müller, Stephen C. Woods, Paul T. Pfluger, Matthias H. Tschöp, Alexandre Fisette, Cristina García-Cáceres

Estradiol regulates leptin sensitivity to control feeding via hypothalamic Cited1

Ismael González-García, Elena García-Clavé, Alberto Cebrian-Serrano, Ophelia Le Thuc, Raian E. Contreras, Yanjun Xu, Tim Gruber, Sonja C. Schriever, Beata Legutko, Jutta Lintelmann, Jerzy Adamski, Wolfgang Wurst, Timo D. Müller, Stephen C. Woods, Paul T. Pfluger, Matthias H. Tschöp, Alexandre Fisette, Cristina García-Cáceres

An analgesic pathway from parvocellular oxytocin neurons to the periaqueductal gray in rats

Mai Iwasaki, Arthur Lefevre, Ferdinand Althammer, Etienne Clauss Creusot, Olga Łąpieś, Hugues Petitjean, Louis Hilfiger, Damien Kerspern, Meggane Melchior, Stephanie Küppers, Quirin Krabichler, Ryan Patwell, Alan Kania, Tim Gruber, Matthew K. Kirchner, Moritz Wimmer, Henning Fröhlich, Laura Dötsch, Jonas Schimmer, Sabine C. Herpertz, Beate Ditzen, Christian P. Schaaf, Kai Schönig, Dusan Bartsch, Anna Gugula, Aleksandra Trenk, Anna Blasiak, Javier E. Stern, Pascal Darbon, Valery Grinevich, Alexandre Charlet

Analysis of the hypothalamic oxytocin system and oxytocin receptor‐expressing astrocytes in a mouse model of <scp>Prader–Willi</scp> syndrome

Ferdinand Althammer, Moritz Claudius Wimmer, Quirin Krabichler, Stephanie Küppers, Jonas Schimmer, Henning Fröhlich, Laura Dötsch, Tim Gruber, Selina Wunsch, Tim Schubert, Matthew K. Kirchner, Javier E. Stern, Alexandre Charlet, Valery Grinevich, Christian P. Schaaf

Diet triggers specific responses of hypothalamic astrocytes in time and region dependent manner

Hypothalamic astrocytes are particularly affected by energy-dense food consumption. How the anatomical location of these glial cells …

Luiza Maria Lutomska, Viktorian Miok, Natalie Krahmer, Ismael González-García, Tim Gruber, Ophelia Le Thuc, Cahuê DB Murat, Beata Legutko, Michael Sterr, Gesine Saher, Heiko Lickert, Timo D. Müller, Siegfried Ussar, Matthias H. Tschöp, Dominik Lutter, Cristina García-Cáceres

Independent phenotypic plasticity axes define distinct obesity sub-types

Studies in genetically ‘identical’ individuals indicate that as much as 50% of complex trait variation cannot be traced to …

Chih-Hsiang Yang, Luca Fagnocchi, Stefanos Apostle, Vanessa Wegert, Salvador Casaní-Galdón, Kathrin Landgraf, Ilaria Panzeri, Erez Dror, Steffen Heyne, Till Wörpel, Darrell P Chandler, Di Lu, Tao Yang, Elizabeth Gibbons, Rita Guerreiro, Jose Bras, Martin Thomasen, Louise G Grunnet, Allan A Vaag, Linn Gillberg, Elin Grundberg, Ana Conesa, Antje Körner, PERMUTE, J Andrew Pospisilik

Astroglial clean-up of satiety synapses

Tim Gruber, Cristina García-Cáceres

Global, neuronal, and beta-cell specific deletion of insulin inhibitory receptor (incep-tor) improves glucose homeostasis in diet-induced obese mice

Gerald Grandl, Gustav Colldén, Ansarullah Ansarullah, Weiwei Xu, Fataneh Fathi Far, Tim Gruber, Aimée Bastidas-Ponce, Qian Zhang, Aaron Novikoff, Cristina García-Cáceres, Matthias Tschöp, Heiko Lickert, Timo Müller

Auto-aggressive CXCR6$mathplus$ CD8 T cells cause liver immune pathology in NASH

Michael Dudek, Dominik Pfister, Sainitin Donakonda, Pamela Filpe, Annika Schneider, Melanie Laschinger, Daniel Hartmann, Norbert Hüser, Philippa Meiser, Felix Bayerl, Donato Inverso, Jennifer Wigger, Marcial Sebode, Rupert Öllinger, Roland Rad, Silke Hegenbarth, Martina Anton, Adrien Guillot, Andrew Bowman, Danijela Heide, Florian Müller, Pierluigi Ramadori, Valentina Leone, Cristina García-Cáceres, Tim Gruber, Gabriel Seifert, Agnieszka M. Kabat, Jan-Philipp Mallm, Simon Reider, Maria Effenberger, Susanne Roth, Adrian T. Billeter, Beat Müller-Stich, Edward J. Pearce, Friedrich Koch-Nolte, Rafael Käser, Herbert Tilg, Robert Thimme, Tobias Boettler, Frank Tacke, Jean-Francois Dufour, Dirk Haller, Peter J. Murray, Ron Heeren, Dietmar Zehn, Jan P. Böttcher, Mathias Heikenwälder, Percy A. Knolle

Active integrins regulate white adipose tissue insulin sensitivity and brown fat thermogenesis

Francisco Javier Ruiz-Ojeda, Jiefu Wang, Theresa Bäcker, Martin Krueger, Samira Zamani, Simon Rosowski, Tim Gruber, Yasuhiro Onogi, Annette Feuchtinger, Tim J. Schulz, Reinhard Fässler, Timo D. Müller, Cristina García-Cáceres, Matthias Meier, Matthias Blüher, Siegfried Ussar

The Neuroanatomical Organization of Hypothalamic Feeding Circuits

Based on early experimental lesion findings, the hypothalamus was historically identified as fundamental for balancing energy intake …

Tim Gruber, Stephen C. Woods, Matthias H. Tschöp, Cristina García-Cáceres

Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension

Summary Pathologies of the micro- and macrovascular systems are a hallmark of the metabolic syndrome, which can lead to chronically …

Tim Gruber, Chenchen Pan, Raian E. Contreras, Tobias Wiedemann, Donald A. Morgan, Alicja A. Skowronski, Sandrine Lefort, Cahuê De Bernardis Murat, Ophelia Le Thuc, Beata Legutko, Francisco J. Ruiz-Ojeda, María de la Fuente-Fernández, Angel Luis García-Villalón, Daniel González-Hedström, Melanie Huber, Klara Szigeti-Buck, Timo D. Müller, Siegfried Ussar, Paul Pfluger, Steve C. Woods, Ali Ertürk, Charles A. LeDuc, Kamal Rahmouni, Miriam Granado, Tamas L. Horvath, Matthias H. Tschöp, Cristina García-Cáceres

Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension

Insulin action on astrocytes: From energy homeostasis to behaviour

Abstract Astrocytes are specialised glial cells that integrate distinct inputs arising from neurones, other glial cells and the …

Ismael González-García, Tim Gruber, Cristina García-Cáceres

Insulin action on astrocytes: From energy homeostasis to behaviour

Control of Systemic Metabolism by Astrocytes in the Brain

Ophelia Le Thuc, Tim Gruber, Matthias H. Tschöp, Cristina García-Cáceres

Targeting glia-vascular interactions for the treatment of obesity and its comorbidities

Metabolic diseases such as obesity confer an increased risk for developing cerebrovascular dysfunction. This thesis reveals that …

Tim Gruber

Functional identity of hypothalamic melanocortin neurons depends on Tbx3

Heterogeneous populations of hypothalamic neurons orchestrate energy balance via the release of specific signatures of neuropeptides. …

Carmelo Quarta, Alexandre Fisette, Yanjun Xu, Gustav Colldén, Beata Legutko, Yu-Ting Tseng, Alexander Reim, Michael Wierer, Maria Caterina De Rosa, Valentina Klaus, Rick Rausch, Vidhu V. Thaker, Elisabeth Graf, Tim M. Strom, Anne-Laure Poher, Tim Gruber, Ophelia Le Thuc, Alberto Cebrian-Serrano, Dhiraj Kabra, Luigi Bellocchio, Stephen C. Woods, Gert O. Pflugfelder, Rubén Nogueiras, Lori Zeltser, Ilona C. Grunwald Kadow, Anne Moon, Cristina García-Cáceres, Matthias Mann, Mathias Treier, Claudia A. Doege, Matthias H. Tschöp

Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes

Pharmacological stimulation of brown adipose tissue (BAT) thermogenesis to increase energy expenditure is progressively being pursued …

Christoffer Clemmensen, Sigrid Jall, Maximilian Kleinert, Carmelo Quarta, Tim Gruber, Josefine Reber, Stephan Sachs, Katrin Fischer, Annette Feuchtinger, Angelos Karlas, Stephanie E. Simonds, Gerald Grandl, Daniela Loher, Eva Sanchez-Quant, Susanne Keipert, Martin Jastroch, Susanna M. Hofmann, Emmani B. M. Nascimento, Patrick Schrauwen, Vasilis Ntziachristos, Michael A. Cowley, Brian Finan, Timo D. Müller, Matthias H. Tschöp

Chronic D-serine supplementation impairs insulin secretion

The metabolic role of d-serine, a non-proteinogenic NMDA receptor co-agonist, is poorly understood. Conversely, inhibition of …

Lisa Suwandhi, Simone Hausmann, Alexander Braun, Tim Gruber, Silke Heinzmann, Eric Gálvez, Achim Buck, Beata Legutko, Andreas Israel, Annette Feuchtinger, Elizabeth Haythorne, Harald Staiger, Martin Heni, Hans Haring, Ph Schmitt-Kopplin, Axel Walch, Cristina García-Cáceres, Matthias Tschöp, Guy Rutter, Siegfried Ussar

Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability

We report that astrocytic insulin signaling co-regulates hypothalamic glucose sensing and systemic glucose metabolism. Postnatal …

Cristina García-Cáceres, Carmelo Quarta, Luis Varela, Yuanqing Gao, Tim Gruber, Beata Legutko, Martin Jastroch, Pia Johansson, Jovica Ninkovic, Chun-Xia Yi, Ophelia Le Thuc, Klara Szigeti-Buck, Weikang Cai, Carola W. Meyer, Paul T. Pfluger, Ana M. Fernandez, Serge Luquet, Stephen C. Woods, Ignacio Torres-Alemán, C. Ronald Kahn, Magdalena Götz, Tamas L. Horvath, Matthias H. Tschöp

A New Population of Parvocellular Oxytocin Neurons Controlling Magnocellular Neuron Activity and Inflammatory Pain Processing

Oxytocin (OT) is a neuropeptide elaborated by the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei. Magnocellular OT …

Marina Eliava, Meggane Melchior, H. ~Sophie Knobloch-Bollmann, Jérôme Wahis, Miriam da~Silva~Gouveia, Yan Tang, Alexandru~Cristian Ciobanu, Rodrigo Triana~del~Rio, Lena~C. Roth, Ferdinand Althammer, Virginie Chavant, Yannick Goumon, Tim Gruber, Nathalie Petit-Demoulière, Marta Busnelli, Bice Chini, Linette~L. Tan, Mariela Mitre, Robert~C. Froemke, Moses~V. Chao, Günter Giese, Rolf Sprengel, Rohini Kuner, Pierrick Poisbeau, Peter~H. Seeburg, Ron Stoop, Alexandre Charlet, Valery Grinevich

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